The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

MYC is a target of the Wnt signalling pathway and governs numerous cellular developmental programmes hijacked in cancers. The amplification frequently occurring genetic alteration cancer genomes, this transcription factor implicated metabolic reprogramming, cell death, angiogenesis In review, we analyse gene networks solid We investigate interaction with long non-coding RNAs (lncRNAs). Furthermore, role regulatory inducing changes to processes, including autophagy mitophagy. Finally, review mutual regulation between lncRNAs, autophagic processes these as unexplored areas targeting manipulation for therapeutic gain MYC-driven malignancies.